The study on the degradation of protopanaxatriol ginsenoside from the roots of SANQI and their anti-inflammatory effects

• Main Authors: LEE YU PO, 理昱博
• Other Authors: Yuh-Shuen Chen
• Format: Others
• Language: zh-TW
• Published: 2017
• Online Access: http://ndltd.ncl.edu.tw/handle/5z6fy4

碩士 === 弘光科技大學 === 食品科技所 === 105 === Panax notoginseng belong to the original araliaceae,is a unique species of China,Originated in Yunnan and Guangxi at the junction of the southern subtropical mountain,grow under the shade of herbs in the forest. Panax notoginseng Contains rich chemical ingredients such as saponins, polysaccharides, polyalkynols and flavonoids and aspartic acid, glutamic acid, arginine and other sixteen kinds of amino acids. In this study, Penicillium.sp was used as the engineering bacteria, and Panax notoginseng root powder was fermented and degrading under appropriate conditions. In this paper, High Performance Liquid Chromatography (HPLC) was developed for the determination of protopanaxatriol ginsenoside , the changes of protopanaxatriol in Panax notoginseng root were studied before and after fermentation. It was found that the ginsenoside Re and Rg1 and Rg2 contained in Panax notoginseng root could be transformed into protopanaxatriol ginsenoside F1 and Rh1.The cytotoxicity test and anti-inflammatory activity.The results showed that Rh1 (R), Rh1 (S) and F1 didn’t affect cell viability at a certain concentration.High concentrations of F1 (100 μM) can reduce the amount of IL-1β elicited by LPS.