1.Synthesis of Chiral Ethers2.Chiral Ether-TiCl4-Mg Promoted Coupling of Bromoform with Aldehydes and Ketones

• Main Authors: Li-Te Lin, 林立得
• Other Authors: 楊圖信
• Format: Others
• Language: zh-TW
• Published: 2017
• Online Access: http://ndltd.ncl.edu.tw/handle/72800420207615273159

碩士 === 國立中興大學 === 化學系所 === 105 === Chiral reagents have played an important role in asymmetric catalytic synthesis. We know many chiral ligands have C2 symmetry which inspired us to develop some methods to synthesize C2 symmetric chiral molecules. In accordance with the report, we use D-mannitol as starting material. D-mannitol was converted into isomannide and then we tried to synthesize some of its derivatives. Finally, we use them to synthesize the chiral ethers 18. Our lab have published several papers by using TiCl4-Mg-ether bimetallic complexes to promote the coupling of Bromoform with a variety of aldehydes and ketones to form alcohol adducts. However, for the lack of TiCl4-Mg-chiral ethers we can’t get the chiral alcohol adducts. What we are interested about is whether we could use TiCl4-Mg-chiral ethers to promote the asymmetric coupling of Bromoform with aldehydes and ketones. The amount of chiral ethers and Different kinds of TiCl4/Mg ratios are able to change the result. Finally, we get the alcohol adducts, but the yield is very low.