Enhancing the Microparticle Deposition Stability and Homogeneity on Planer by Mask, Lengthened Nozzle and Flow Adjustment

• Main Authors: Shih, An-Ci, 石安旗
• Other Authors: Cheng, Yun-Chien
• Format: Others
• Language: zh-TW
• Published: 2017
• Online Access: http://ndltd.ncl.edu.tw/handle/14644813529874292462

碩士 === 國立交通大學 === 機械工程系所 === 105 === This study is focus on improving the process of particle-based synthesis of peptide microarray with CMOS chip. In this method, high pressure stream is required for pouring into particle reservoir with a large number of bio-particles, and high pressure stream impact bio-particles to form aerosol. The turbulence of flow affects aerosol and then make particle depositing inhomogeneously on the chip surface. This phenomenon severely affects the reliability of the peptide microarrays. The research objective is to improve this phenomenon, so we build up a set of experimental system and replace bio-particle with carbon toner for doing deposition experiments. We use numerical simulations comparing with experimental results. In simulations, we use FLUENT to simulate the flow field of different nozzles, and then do experiments to verify the simulation results. In experimental results, when different pressure and flow rate are applied to experiments, it is found that carbon toner affected by ring vortex and formed a ring-shaped blank area. Therefore we use mask to restrict deposition area of particles. This is proved by experiments and simulation that mask effectively reduces the influences of ring vortex. Finally, the pressure affects the thickness of particle layer under the condition of fixed flow rate, and flow rate is the main condition for ring vortex phenomenon under the condition of fixed pressure.