Chemical constituents and anti-inflammatory activity of the soft coral Lobophytum sp.

• Main Authors: Wan-Jing You, 尤婉靜
• Other Authors: Jui-Hsin Su
• Format: Others
• Published: 2017
• Online Access: http://ndltd.ncl.edu.tw/handle/74881653715287130105

碩士 === 國立東華大學 === 海洋生物研究所 === 105 === Diterpenes of the cembrane type are some of the most frequently encountered natural products in soft corals of the genus Lobophytum. Of particular interest, cembranoids have been reported to possess several kinds of biological activities, such as antitumor, antimicrobial and anti-inflammatory activities. During the course of our study on the anti-inflammatory chemical constituents from a wild-type soft coral Lobophytum sp., two new cembranoids, lobophyolide A (1) and B (2), along with five known compounds (3–7) have been isolated. The structures of these natural products were identified using NMR analyses, as well as data from mass spectroscopic methods. The in vitro anti-inflammatory effects of compounds 1, 2, 5, 6, 7 were also tested. The results showed that compounds 1, 2, 5, 6, 7 reduced IL-12 production from LPSstimulated dendritic cell. Moreover, compounds 1, 2, 5, 6, 7 reduced NO release from LPS-activated DCs. Accordingly, our data indicated that compounds1, 2, 5, 6, 7 exhibited as an outstanding lead for the development of anti-inflammatory agent.