Detection of pancreas cancer markers CEA and CA19-9 antigen by AlGaN/GaN high electron mobility transistor biosensor

• Main Authors: Pei-Hsien Chen, 陳佩賢
• Other Authors: Li-Wei Tu
• Format: Others
• Language: zh-TW
• Published: 2017
• Online Access: http://ndltd.ncl.edu.tw/handle/99vfag

碩士 === 國立中山大學 === 物理學系研究所 === 105 === AlGaN / GaN high electron mobility transistors (HEMTs) have the advantages of high electron mobility, high sensitivity, and high efficiency. Therefore, HEMTs are suitable for the detection of biomolecules with very little charge and can utilize HEMTs to develop biosensor. The aim of this study is to investigate the application of AlGaN / GaN HEMT in the detection of biomolecules, and to make rapid screening, small size and convenient biosensor. AlGaN/GaN HEMT hetero structure interface form a two-dimensional electron gas (2DEG). The bio-molecules bind on the HEMT surface will change the electron concentration of 2DEG. When biomolecules bind with the AlGaN/GaN HEMT, the electron concentration in the 2DEG structure will change. We use LabVIEW software to measure the immediate current and the conductance change. In this study, CEA and CA19-9 antigen cancer tumor markers are detected to increase the reliability of the biosensor. Two sensing areas are respectively modified with different antibodies. When the liquid within two antigens flows through the sensing areas, and can be detected separately.