| Summary: | 碩士 === 國立臺灣師範大學 === 生命科學系 === 105 === Women will go through some complications, such as obesity, uterine shrinking, increase in oxidative stress, decrease in blood flow, change in the expression of estrogen and progesterone receptor, etc, for peri- and postmenopausal women when they come to the certain age.
Along with the aging tendency in the world, and female average life expectancy is higher than male, climacteric syndromes is going to be an important issue in the future, but the Modern Medicine which was usually used to treat them got lots of side effects. We, therefore, intend to try more moderate traditional Chinese medicine.
To evaluate the estrogenic effect of the Chinese herbal formula B401, we examined uterine weight, body weight, blood flow, ROS (reactive oxygen species), SOD2 (superoxide dismutase 2), estrogen receptor (ER), progesterone receptor (PR) activation by B401 treatment in vivo ovariectomized mice. The female mice were randomized into four groups: Sham operated group (Sham), saline treated ovariectomized group (OVT) and B401 treated ovariectomized group (B401+OVT). The B401+OVT mice were oral treated with B401 at a dose of 30 mg/kg bw/day for 10 days. Our results showed that oral treatment with the Chinese herbal formula B401 significantly reversed ovariectomy-induced uterine weight reduction. Moreover, the Chinese herbal formula B401 oral treatment significantly increased blood flow, expression of ERβ and PR in the uterus, and decrease in ovariectomized mice ROS, expression of ERα and SOD2 in the uterus. Taken our data together, we suggested that B401 oral treatment could be protective and beneficial for the management of menopausal symptoms.
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