Strontium-Doped Calcium Sulfate Anhydrate as Bone Graft Substitute

• Main Authors: Man-Ping Chang, 張曼蘋
• Other Authors: Wei-Hsing Tuan
• Format: Others
• Language: en_US
• Published: 2017
• Online Access: http://ndltd.ncl.edu.tw/handle/pmfe35

博士 === 國立臺灣大學 === 材料科學與工程學研究所 === 105 === Calcium sulfate (CaSO4, CS) has been used as bone graft substitute for more than 100 years. It exhibits well-tolerated and biocompatible properties, osseointegration and osteoconduction. Therefore, calcium sulfate implant induces minimal inflammatory responses in vivo, and can support bone cells to growth over it surface. In addition, calcium sulfate can be resorbed in vivo completely, it is an important property for a bone graft substitute that can avoid additional operation for implant removal. Strontium ion is known for its antiosteoporotic effect. The mechanism is a dual mode that strontium can enhance bone formation and inhibit bone resorption simultaneously. For bone formation, strontium can stimulate the replication of preosteoblast and induce the secretion of collagen, leading to increase bone matrix. In parallel, strontium can inhibit the differentiation and activity of osteoclasts by upregulation the ratio of osteoprotegerin (OPG) / receptor activator of nuclear factor kappa-B ligand (RANKL) in osteoclast, and leading to the decrease of bone resorption In the present study, sintering technique is used to prepare calcium sulfate anhydrate specimens incorporating strontium ion. An amount of 10wt% strontium sulfate powder is added into calcium sulfate hemihydrate powder, then sintered at 1200°C for 1 hour to form the strontium-substituted calcium sulfate. The degradation results show that strontium ion release during the specimen degradation simultaneously. In addition, both indirect and direct cytotoxicity results demonstrate the biocompatibility. In conclusion, the strontium-substituted calcium sulfate specimen is a potential material that not only bioresorbable but antiosteoporotic as a novel bone graft substitute.