The Connectomic Characteristics of Drosophila Brain Studied by Complex Network Methods

• Main Authors: LEE, MENG-HSUN, 李孟勳
• Other Authors: SHIH, CHI-TIN
• Format: Others
• Language: zh-TW
• Published: 2017
• Online Access: http://ndltd.ncl.edu.tw/handle/93a3u6

碩士 === 東海大學 === 應用物理學系 === 105 === Background: To understand the mode of the information flow in the brain is the one of main purposes in neuroscience. In this thesis, we constructed the draft of female Drosophila connectome in mesoscopic scale from 22809 single-neuron images. Method: First, we predicted the polarity of the fibers according to criteria of their morphology, and identified the dendritic and axonal fibers of each neuron, and the brain regions called local processing units (LPUs) they innervated. Then we constructed the network of the drosophila brain, which was composed of the LPUs as the nodes of the network. The weight of directed edge connecting two LPUs was calculated by the number of endpoints of all neurons connecting them. Finally, the construction had been done. We studied the network using the complex network theory. Results: The network has small-word characteristic and modular structure. It contains five function modules that correspond four sensory modalities (olfaction, mechanic/audition, vision for left and right sides) and one pre-motor center. The LPUs having high centralities are also identified.