Analysis of cathinones in urine by chromatography/mass spectrometry

• Main Authors: Shih-Shan Lin, 林詩珊
• Other Authors: Sheng-Meng Wang
• Format: Others
• Language: zh-TW
• Published: 2018
• Online Access: http://ndltd.ncl.edu.tw/handle/35g9tu

碩士 === 中央警察大學 === 鑑識科學研究所 === 106 === Numerous criminal problems are derived from drug abuse, such as social security and lose of social cost. Especially, the sale and recreational use of New psychoactive substances (NPS) increase rapidly in recent years. NPS are developed to mimic the effects of known illegal drugs of abuse in order to evade criminal penalties. Because its growth and development is too fast, control of NPS is not easy, making the resulting social harm is very serious. NPS have become one of important issues for drug control. It is a challenge for examination of all NPS. In this study, the mass spectrums library of synthetic cathinone (a kind of NPS) in LC-QTOF/MS has been built. With urine sample as matrix, we have been evaluated the method for analysis of synthetic cathinone. In method validation, we evaluates calibration curves, LOD, LOQ, recovery and intra- inter-day assay. Calibration curves of synthetic cathinone are linear (R2 >0.99) between 10-1000 ng.ml. Recovery efficiencies range from 82.91 to 103.31% except from 3-FMC. Matrix effects range from -20% to 20% except for methylone (35%) and 3-FMC (-58%). In this study, we hope the established method for analysis of synthetic cathinone could effectively combat emerging drugs