| Summary: | 碩士 === 中山醫學大學 === 公共衛生學系碩士班 === 106 === APOA5 rs662799 has been associated with cardiovascular diseases and mortality, partly due to its effects on serum lipid profiles. The relationship between high density lipoprotein-cholesterol (HDL-C) and APOA5 rs662799 has not been fully elucidated by gender. This study aimed to compare HDL-C among Hakkaness and non-Hakkaness individuals. Demographic and genotypic data were obtained from Taiwan Biobank. Multivariate linear regression analysis was used to examine factors significantly and independently associated with different categories of genotypes and to estimate the β value of HDL-C.A total of 657 Hakkaness (263 men and 394 women) and 7448 non-Hakkaness (3496 men and 3952 women) participants were enrolled. Multivariate linear regression analysis showed significant associations among Hakkaness individuals with GG genotypes (β=-5.068, P=0.002). However, no significant effects was found among GA carriers (β=-0.873, P=0.334). HDL-C levels was significantly decreased among non-Hakkaness individuals with GA (β=-1.670, P=<0.000) and GG genotypes (β=-3.424, P=<0.000). Lower levels of HDL-C were found among Hakkaness women with GA (β=-3.050, P=0.020) and GG genotypes (β=-6.876, P=0.001) . However, no significant association was found among Hakkaness men with GA (β=2.268, P=0.07) and GG (β=-1146, P=0.672) genotypes. Among non-Hakkaness females, GA and GG genotypes were significantly associated with lower HDL-C compared with AA genotypes. Their beta values were -1.838 (P =<0.000 ) and -3.983( P=<0.000), respectively. Among non-Hakkaness men, both GA and GG genotypes were associated with lower HDL-C compared with the AA genotypes. Their beta values were -1.374, P =<0.000 and -2.796, P=<0.000, respectively. In conclusion, GA and GG genotypes were found to be significantly associated with decreased concentrations of HDL-C in all individuals except the Hakkaness men.
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