Surface Modification of Polystyrene by Zwitterionic Self-Assembly for High-Throughput Diagnostics
碩士 === 中原大學 === 化學工程研究所 === 106 === The development of nonfouling surfaces is therefore critically important in biomedical applications. Scientists began to develop zwitterionic antifouling materials based on the natural bio-inert theory that was inspired by the cell membrane[1, 2]. Despite their ex...
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| Format: | Others |
| Language: | zh-TW |
| Published: |
2018
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| Online Access: | http://ndltd.ncl.edu.tw/handle/c69pht |
| Summary: | 碩士 === 中原大學 === 化學工程研究所 === 106 === The development of nonfouling surfaces is therefore critically important in
biomedical applications. Scientists began to develop zwitterionic antifouling materials based
on the natural bio-inert theory that was inspired by the cell membrane[1, 2].
Despite their excellent fouling resistance, solubility issues of amphiphilic
zwitterionic copolymers limit their use in surface modifications by coating[3]. This work
presented an innovative method to form bio-inert interface. The strategy to create bio-inert
interfaces in biological systems via hydrophobic interaction and ion -pair anchoring of
zwitterionic copolymer brushes and a systematic study of how well-defined charges of the
amphiphilic copolymers and zwitterionic copolymers and well -controlled surface of
amp h ip h il i c co p ol ymer an d zwit t er io n i c co p o l ymer s aff ect b iocomp ati b il it y i s
reported.Poly([2-(Methacryloyloxy)ethyl]trimethylammonium)- block -poly-(styrene) - block
- poly([2-(Methacryloyloxy)-ethyl]trimethylammonium) (PTMA- b -PS- b -PTMA) with
var ying h ydrophobic PS segment and pol y(3 -Sulfoprop yl methacr ylate) - block -
poly(sulfobetaine methacrylate) (PSBMA- b -PSA) with varying negatively charged PSA
lengths. via reverse radical addition-fragment chain transfer (RAFT).PTMA-b-PS-b-PTMA is
coated on the polystyrene plate by hydrophobic interaction and PSA- b -PSBMA is coated on
a surface covered with polycation brush via ion-pair anchoring.
The advantages of the method are a very fast modification process and a
modification without pretreatment. The results showed that the low fouling surface with
respect to uncoated surface are achieved with shorter PS segment of triblock copolymer and
shorter SA segment of diblock copolymer. Compare to PS Plate, the modified PS Plate has
high sensitivity in blood typing. This kind of antifouling PS Plate has potential to develop
high selectivity diagnosis in human blood.
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