1. Synthesis of C2-symmetric Chiral Ether2. To explore the chiral Ether-TiCl4-Mg-promoted asymmetric coupling of CHBr3 with ketone

• Main Authors: jia-jeng Lin, 林家正
• Other Authors: Tu-Hsin Yan
• Format: Others
• Language: zh-TW
• Published: 2018
• Online Access: http://ndltd.ncl.edu.tw/handle/7nrqrn

碩士 === 國立中興大學 === 化學系所 === 106 === Usually chiral ethers have C2 symmetry and play an important role in asymmetric catalytic synthesis. So that we want to create chiral ligand contain C2 symmetry. We use THF as the target structure, Reference other people paper. Using glucosamine hydrochloride as starting material, and modify it to our finial material chiral ether. Our lad have published several papers about using TiCl4-Mg bimetallic complexes to induce aldehyde and ketone to conduct Methylation or 1, 2 addition with THF or DME, and the product is alcohol. In different rate of TiCl4 and Mg, have different product. But without chiral ligand, can not choose what type of product, so we want to create chiral ether.