| Summary: | 博士 === 國立中央大學 === 系統生物與生物資訊研究所 === 106 === Complex diseases such as cancer, neurodegenerative disorders, diabetes mellitus, and cardiovascular disease are associated with altered interactions between thousands of genes. Although variants in many genetic and environmental factors have been associated with complex diseases, inter-disease relations remains largely unexplored. Here, based on nineteen gene expression datasets on six complex diseases – type 2 diabetes, chronic kidney disorder, Alzheimer’s disease, thyroid cancer, Gaucher disease, and multiple sclerosis – we construct functional genomic analysis of the diseases, explore functional similarity/dissimilarity among the diseases, and identify function-associated genotype-unique significant genes for the diseases. Our results suggest many validating experiments and provide useful information for the prevention, diagnostic, and treatment of the six complex diseases.
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