Association of urinary metals and 1-hydroxypyrene with lung function in shipyard welding workers

• Main Authors: CHIEN, CHIH-YU, 簡志育
• Other Authors: LAI, CHING-HUANG
• Format: Others
• Language: zh-TW
• Published: 2018
• Online Access: http://ndltd.ncl.edu.tw/handle/a669zc

碩士 === 國防醫學院 === 公共衛生學研究所 === 106 === Background Taiwan is an island surrounded by sea and therefore the development of shipbuilding industry is well deployed. The work of many shipyard workers involves welding, cutting and grinding. Welders exposed to the high concentration of hazardous substances as metal fume or dust, and the hazardous substances can have a significant impact on their health. The decreasing of lung function will increase the risk of death is connecting with the diseases as cardiovascular disease and chronic obstructive pulmonary disease. As a result, it is necessary to know the relations between the exposure to metal pollutants and the lung function. Objectives The purpose of this study was to investigate the association between the biomarkers of exposure [urinary metals and urinary (1-hydroxypyrene, 1-OHP)] and respiratory health effects FVC (Forced vital capacity), FEV1 (Forced expiratory volume in one second), FEV1/FVC, MMF (Maximal mid-expiratory flow), FEF25%-75% (Forced expiratory flow rate 25%-75%), PEF (Peak expiratory flow) and FENO (Fractional exhaled nitric oxide) by using a longitudinal design. Methods The subjects of this study were the recruited from one of the shipyards in northern Taiwan. In four consecutive years, started in September in 2014, personal air sampling, questionnaire and health examination were administered to collect data. Data collection strategy included subjects were requested to wear a PM2.5 personal sampler on Monday morning for their 8-hour personal sampling. And for the next day (Tuesday) morning, health examination including urine collection and fasting blood samples were collected. A questionnaire was administered to collect personal information, life style and working habits. Biomarkers of exposure included urinary metals and urinary 1-hydroxypyrene (1-OHP). Respiratory health effects included FVC (Forced vital capacity), FEV1 (Forced expiratory volume in one second), FEV1/FVC, MMF (Maximal mid-expiratory flow), FEF25%-75% (Forced expiratory flow rate 25%-75%), PEF (Peak expiratory flow) and FENO (Fractional exhaled nitric oxide). Result Generalized Estimation Equation (GEE) analyses adjusted variables included age, weight, smoking habit, secondhand smoke, year of data collection, urinary creatinine (μg/g Creatinine) and PM2.5 levels. Results showed that as urinary Manganese increased, FEV1%(β=-0.028; p=0.033), PEF(β=-0.041; p=0.039) and PEF%(β=-0.042; p=0.029) decreased, Cobalt increased, FEV1(β=-0.026; p=0.041), FEV1/FVC(β=-0.012; p<0.001), FEV1/FVC%(β=-0.008; p=0.008) and MMF(β=-0.035; p=0.020) decreased, Cadmium increased, FEV1(β=-0.028; p=0.039) decreased, Copper increased, FEV1/FVC(β=-0.059; p=0.004), FEV1/FVC%(β=-0.047; p=0.031) and MMF(β=-0.200; p=0.030) decreased, Iron increased, FVC(β=-0.026; p=0.043) and FVC%(β=-0.031; p=0.005) decreased, but Nickel in urine increased, FEV1/FVC(β=0.005; p=0.028) and FEV1/FVC%(β=0.007; p=0.006) increased. And with the Cobalt (β=0.080; p=0.003) and Nickel (β=0.053; p=0.019) in urine increased, the FENO increased, but with the PM2.5 (β=-0.038; p=0.043) and 1-OHP (β=-0.144; p= 0.015) in urine increased, the FENO decreased. Conclusion The increasing of biomarkers of exposure of urinary Manganese, Cobalt, Cadmium, Copper, and Iron are associated with decreased lung function. But urinary Nickel is associated with increased lung function. Urinary Cobalt and Nickel are associated with increased FENO. PM2.5 and urinary 1-OHP are associated with increased FENO. Keywords: Metals, Polycyclic aromatic hydrocarbons, 1-OHP, Lung function, FENO, Welding workers