| Summary: | 碩士 === 國立高雄第一科技大學 === 環境與安全衛生工程系消防與防災工程碩士在職專班 === 106 === Background: A number of studies have explored the associations between air pollution and cardiovascular diseases. However, there are few investigations of the impacts of short-term exposure to air pollutants and out-of-hospital cardiac arrest (OHCA) and their findings are inconsistent. This study evaluated the associations between short-term exposure to outdoor air pollution and the risk of OHCA among residents in Kaohsiung, a metropolis in southern Taiwan.
Methods: We collected OHCA data from Fire Department of Kaohsiung City Government and air pollutants data from Environmental Protection Administration of Executive Yuan of Taiwan in 2014. A time-stratified case-crossover design was used to investigate the association between air pollution levels and OHCA. A total of 2320 cases of OHCA were used to evaluate the odds ratio (OR) of air pollutants at lag 0, lag 1, lag 2, and lag 3 and stratified for age, gender, and previous disease history.
Results: After adjusted for temperature and humidity, reported data underline a significant of every increase of interquartile range (IQR) of PM2.5 (OR 1.146; 95% CI 1.020-1.28, p=0.022), PM10 (OR 1.186; 95% CI 1.053-1.337, p=0.005), and O3 (OR 1.104; 95% CI 1.017-1.199, p=0.018) on OHCA at lag 1. The adjusted OR for lag 3 exposure to NO2 with an increment of IQR was 1.027 (95% CI 1.003-1.053, p=0.046). Stratified analysis for subgroups of age less than 65 years old, female, and without previous disease history showed a higher susceptibility of air pollutants-induced OHCA.
Conclusions: Exposure to PM2.5, PM10, and O3 at lag 1 and NO2 at lag 3 might significant increase the risk of OHCA among residents in Kaohsiung City. Our study suggested the time of OHCA occurrence might be associated with the kind of air pollutants. There was a higher susceptibility of air pollutants-induced OHCA with age less than 65 years old, female, and without previous disease history. However, the mechanism for OHCA induced by air pollutants remains to be further clarified.
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