Facile Synthesis of Dibenzosuberones via Palladium(II)-Catalyzed Intramolecular C-H Activation/C-C Coupling of Ortho-Aroylated 3,5-Diarylisoxazole

• Main Authors: TUNG CHAO, 趙瞳
• Other Authors: Ming-Jung Wu
• Format: Others
• Language: zh-TW
• Published: 2018
• Online Access: http://ndltd.ncl.edu.tw/handle/vjczqa

碩士 === 國立中山大學 === 化學系研究所 === 106 === Compounds containing the dibenzosuberone skeleton always show diverse biological activities, hence we are interesting in developing synthetic methodology for affording novel dibenzosuberone derivatives by using the compound, phenyl(2-(5-phenylisoxazol-3-yl)phenyl)methanone, that had been synthesised earlier in our lab. A method via palladium-catalyzed C-H activation for the synthesis of dibenzosuberones derivatives from phenyl(2-(5-phenylisoxazol-3-yl)phenyl)methanone was presented in this report. Furthermore, the dibenzosuberone products also bearing a isoxazole group, so we can expect that it will apply for drug development and also show good tolerance of functional groups.