| Summary: | 碩士 === 國立臺灣大學 === 高分子科學與工程學研究所 === 106 === The biodegradable shape memory polymers are candidate materials for making biomedical devices and scaffolds for tissue engineering. Superparamagnetic iron oxide nanoparticles (SPIO NPs) have been reported to promote the osteogenesis of human mesenchymal stem cells (hMSCs). In this study, we synthesize water-based biodegradable shape memory polyurethane (PU) as the main component of the 3D printing ink for fabricating bone scaffolds. The 3D printing ink contains 500 ppm SPIO NPs to promote osteogenic induction and shape fixity, and it also contains polyethylene oxide (PEO) or gelatin for the improvement of printability. Scaffolds are printed by the microextrusion-based low-temperature fuse deposition manufacturing platform. Shape memory properties are evaluated in 50C air and 37C water. PU-PEO scaffolds show better shape fixity and recovery than PU-gelatin scaffolds, while the shape memory properties in water are better than those in air. hMSCs are seeded for evaluation of bone regeneration. With SPIO in the scaffolds, the osteogenesis increases 2.7 times for PU/PEO and 1.5 times for PU/gelatin scaffolds based on the collagen content. We conclude that 3D printed PU scaffolds with shape memory properties, biodegradability and osteogenic effect may be employed as customized-bone substitutes for bone tissue engineering.
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