A Development of Microfluidic Technology for Blood Coagulation Diagnosis

• Main Authors: Jhu-Siang Jheng, 鄭竹翔
• Other Authors: Chih-Ting Lin
• Format: Others
• Language: zh-TW
• Published: 2018
• Online Access: http://ndltd.ncl.edu.tw/handle/s94zss

碩士 === 國立臺灣大學 === 電子工程學研究所 === 106 === The detection of anticoagulant dosage in blood is important and necessary in clinical operations. With high anticoagulant dosage, it will cause heavy bleeding during surgery. In the opposite, it will lead to clotting problem with low anticoagulant dosage. To monitor the dosage, PT and APTT are used in hospitals. However, both PT and APTT are complicated and time-consuming. To overcome these obstacles, in this work, electrical impedance and physical viscosity are employed to monitor the anticoagulant dosage. For the electro-impedance analysis, different electrode design were designed and implemented to obtain the best electrode configuration for blood coagulation measurement. For the physical viscosity analysis, capillary microchannels with different channel width are used to monitor the viscosity characteristics of blood. By using both electro-impedance and physical viscosity methods, the dosage of anticoagulant can be distinguished. This work demonstrates a potential micro devices for anticoagulant dosage monitoring and it could be contributed in clinical applications.