The development of nanoparticles for Helicobacter pylori eradication therapy

• Main Authors: Chung-Huan Huang, 黃仲歡
• Other Authors: 謝銘鈞
• Format: Others
• Language: zh-TW
• Published: 2018
• Online Access: http://ndltd.ncl.edu.tw/handle/ydq9q4

碩士 === 國立臺灣大學 === 醫學工程學研究所 === 106 === Helicobacter pylori (H. pylori) infection is the main cause of gastritis, gastroduodenal ulcers and gastric cancer. H. pylori eradication has been shown to have a prophylactic effect against gastric cancer. However, the long treatment time, large single dose of drug, and side effects of eradication therapy often lead to treatment failure. In this study, the magnetic nanoparticles combined with chitosan and polyacrylic acid (PAA) is used as a drug nanoparticle for H. pylori eradication therapy. The muco-adhesive property of chitosan allows nanoparticles to adhere on the gastric mucosa. The location and residence time of nanoparticles could be controlled by the magnetic nanoparticles via magnetic field change. The addition of PAA could be used to compete with the drug for chitosan, so that drugs could be quickly released in the gastric mucosa for H. pylori eradication. Finally, the use of this nanoparticles could prolong the drug residence time in the stomach, reducing the drug dose and treatment time.