| Summary: | 碩士 === 國立臺灣大學 === 職業醫學與工業衛生研究所 === 106 === ABSTRACT: PART I
Background: Air pollution from biomass burning were associated with neurodevelopmental deceleration, but limited studies concerned about the effect of indoor biomass burning. Incense burning is a common household ritual practice in Taiwan, and yet past studies mainly focused on birth weight and allergic disease.
Objectives: We aimed to find the association between incense burning exposure and children’s neurodevelopment.
Methods: In Taiwan Birth Cohort Study (TBCS), a nationwide representative birth cohort study, children were assessed upon home interview with structured questionnaires at six and eighteen months old. Multivariate logistic and Cox proportional hazard regression adjusting confounding factors were applied to examine the odds ratio (OR) and hazard ratio (HR) between household incense burning exposure and caregiver-reported neurodevelopment milestones.
Results: In this study, 15,310 term singletons were included, and household incense burning was associated with delay in gross motor neurodevelopment milestone, such as walking with support (Occasional incense burning: OR = 1.26, 95% confidence interval (CI): 1.08 to 1.47, HR= 1.07, 95% CI: 1.03 to 1.11; persistent incense burning : OR = 1.44, 95% CI: 1.22 to 1.69, HR= 1.11, 95% CI: 1.07 to 1.16) and walking steadily (Occasional incense burning: OR = 1.14, 95% CI: 0.98 to 1.32, HR= 1.07, 95% CI: 1.03 to 1.11, persistent incense burning : OR = 1.24, 95% CI: 1.06 to 1.45, HR= 1.09, 95% CI: 1.04 to 1.13).
Conclusions: Our study suggested household incense burning exposure was associated with delay in gross motor milestones. Further research is warranted to elucidate the possible mechanism and causal relationship.
ABSTRACT: PART II
Background: Maternal shift work has been found to associate with preterm delivery, childhood obesity and future behavioural problems. However, the adverse effects on and interactions of maternal shift work on infant neurodevelopment remain uncertain. Therefore, we aimed to examine the associations between maternal shift work status and infant neurodevelopmental parameters.
Methods: The Taiwan Birth Cohort Study (TBCS) is a nationwide birth cohort study following representatively sampled mother-infant pairs dyads since 2005. The participants’ development and exposure conditions were assessed by home interview with structured questionnaires at six and eighteen months of age. Propensity scores were calculated with predefined covariates for 1:1 matching. Multivariate conditional logistic regression and the Cox proportional hazards model were used to examine the association between maternal shift work status and caregiver-reported infant neurodevelopmental milestones.
Results: In this study, 5 813 term singletons were included, with 1 900 cases selected in the propensity score-matched subpopulation. Persistent maternal shift work was associated with an increased risk of delay in caregiver-reported gross motor milestones (adjusted odds ratio (aOR)=1.30, 95% confidence interval (CI) =1.02-1.66 for walking with support; aOR=1.41, 95% CI=1.10-1.79 for walking steadily; adjusted hazard ratio (aHR)=1.08, 95% CI=1.01-1.17 for walking with support; aHR=1.07, 95% CI=1.00 to 1.16 for walking steadily). Moreover, delayed fine motor and social development were shown in the propensity score-matched subcohort.
Conclusions: This study shows significant negative associations between maternal shift work and delayed neurodevelopmental milestone achievement in the gross motor, fine motor and social milestones at eighteen months of age. Future research is indicated to elucidate the possible underlying mechanisms and long-term health effects.
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