| Summary: | 碩士 === 國立臺灣大學 === 流行病學與預防醫學研究所 === 106 === The differences of clinicopathological features and survival between Asian and Western breast cancer remained to be elucidated. Recent studies showed that composition of tumor infiltrating immune cells was associated with patients'' survival. To evaluate survival impact of tumor infiltrating immune, two algorithms were used to infer the amount and subtypes of infiltrating immune cells from gene expression profiles, which presented as immune score and percentage of each immune cell. 9 Gene Expression Omnibus datasets and breast cancer dataset of The Cancer Genome Atlas project were included in this study. Compared with Western patients, Asian had significantly higher immune score, more favorable overall survival and disease free survival. Higher immune score was associated with a more favorable prognosis. In terms of treatment response and immune cell composition, there was no significant difference between Asian and Western. The survival impact of immune cells varies across races and survival endpoints. Only high signature of activated CD4 T cell was significantly associated with favorable prognosis in overall survival and disease free survival. In summary, Asian breast cancer patients had more favorable prognosis than Western, partly contributed by higher tumor infiltrating immune cells.
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