Feasibility of fMRS using visual stimulation at 3T MR system

• Main Authors: Jun-Wei Ye, 葉俊緯
• Other Authors: Yi-Ru Lin
• Format: Others
• Language: en_US
• Published: 2018
• Online Access: http://ndltd.ncl.edu.tw/handle/5w6b3m

碩士 === 國立臺灣科技大學 === 電子工程系 === 106 === Functional magnetic resonance spectroscopy has been used to observe brain metabolism during physical stimulation in a non-invasive way. Recent researches have indicated that metabolic concentration changed during visual and motor stimuli using fMRS at 7T system. These studies also showed that glutamate (Glu) and lactate (Lac) have been found to increase by 2% and 17% during stimuli using block design in experiments. The main purpose is to find out the potential of fMRS at 3T system by observing the metabolic change during visual stimulation. Three blocks of black background image and two blocks of flashing checkerboard were interleaved as stimuli material and voxel was located at primary visual cortex. The total fMRS experiment time was about 10 minutes. Our preliminary results showed that concentration of metabolites did not have significant change. But BOLD contrast changed during activation periods. This phenomenon might be related to the placement of VOI. It is possible to observe the metabolic change using fMRS at 3T system if the VOI can be positioned more precisely according to really reactive area.