| Summary: | 碩士 === 臺北市立大學 === 運動健康科學系碩士班 === 106 === Abstract
Outcome of stroke is influenced by many factors and one of them is inflammation. Neutrophil and lymphocyte ratio (NLR) has been proved as systemic inflammation marker which is less influenced by dehydration and exercise. Several studies had showed the NLR is strongly associated with stroke outcome and severity. This study is to investigate the relation between systemic inflammation status and short-term outcome of patients at 10 weeks after stroke in the post-acute care ward. We also want to find out the proper value of NLR as a practical and independent prognostic factor for stroke patients which might change our treatment strategy. The 111 patients admitted to the Rehabilitation Department of New Taipei Jen-Kang Hospital diagnosed with ischemic and haemorrhagic stroke after 4 weeks treatment of acute stage. We divided the patients into high NLR group (NLR> 3.01, n=55, 4.36±1.13) and low NLR group (NLR≤2.99, n=56, 2.18±0.56) according to the fasting blood sample collected at admis-sion. The functional outcome of patients was evaluated at 6 weeks after admission. The function outcome includes modified Rankin Scale (mRS), Barthel index (BI), functional oral intake scale (FOIS), EuroQol Five Dimensions (EuroQoL-5D), minimal nutrition assessment (MNA), and instrumental activities of daily life (IADL) were significant improved in both groups after 6 weeks rehabilitation training. However, the degree of improvement was greater in the lower NLR group (NLR ≤2.99) with mRS (p=0.007) and MNA score (p=0.002). The NLR was failed to correlate to BI (p=0.068), FOIS (p=0.307), EuroQoL 5-D (0.696), and IADL (p=0.562) improvement after rehabilitation program training. The patients with lower systemic inflammation status (NLR≤2.99) has less dependency of daily life and better nutrition status at 10 weeks after stroke than those with higher inflammation status (NLR>3.01) according the fasting blood exami-nation at 4 weeks after stroke
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