| Summary: | 碩士 === 國立陽明大學 === 生命科學系暨基因體科學研究所 === 106 === As migrating out of Africa, human was exposed to new environments, diets, and pathogens, and forced to adapt. Identifying genomic signatures of evolutionary adaptation can uncover the history of population adaptation events and reveal the underlying biological mechanisms. In this study, I applied integrated haplotype score (iHS), a linkage disequilibrium-based method for detecting genomic signatures of recent positive selection in Taiwanese populations including Taiwanese Han and the aboriginal populations living in Taitung. I first investigated possible causes that could inflate iHS scores in addition to selection and discovered that iHS scores tend to elevated for loci near a centromere or in the region of low recombination rates. I next filtered out some outliers that are less likely caused by natural selection. As a result, 26 loci were identified as candidates targeted by natural selection in Taiwanese Han people while 12 loci were identified for the people living in Taitung. These two populations appear to have different loci targeted by natural selection, likely reflecting their distinct evolutionary history in the past. In addition, some candidate loci are found located at or near the gene associated with disease, such as liver and colorectal cancer and gout.
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