Synthesis of Monodisperse Magnetite and Carbon Dots/Magnetite Nanocomposites for Biomedical Application

• Main Authors: Shen-Yuan Lee, 李申元
• Other Authors: An-Cheng Sun
• Format: Others
• Language: en_US
• Published: 2018
• Online Access: http://ndltd.ncl.edu.tw/handle/78d56a

碩士 === 元智大學 === 化學工程與材料科學學系 === 106 === Magnetite (Fe3O4) nanoparticle have attracted much attention due to the superparamagnetic properties, biocompatibility and low toxicity which are promising candidates in application in biomaterials to the synthetic scaffolds, drug carriers, sensing media, etc. In addition, the size, dispersity and magnetic property of the magnetic nanoparticles are significance in biomedical applications. In order to obtain uniform particle size, hydrophilic surface and aqueous dispersibility, the solvothermal method was proposed in this study. The anionic polyelectrolyte poly(4-styrenesulfonic acid-co-maleic acid) sodium salt (PSSMA) was used as a stabilizer to synthesis of electrostatic stabilization magnetite nanoparticles since it can strongly coordinate to iron cation to form linear polymeric molecules further restrain grain growth and the containing carboxyl groups can modify particle surface to be hydrophilic. Results pointed out that the magnetic nanoparticles with excellent water dispersity and uniform size were synthesized by modified solvothermal method. It was found that the water plays a crucial role in the process of hydrolysis. Without the addition of water, the minor phase will formed instead of magnetite. Furthermore, the size of nanoparticle can be tunable in range of 117.7 to 217.6 nm were developed by changing amount of water, PSSMA and sodium hydroxide. The results further confirm PSSMA not only provide the nanoparticles electrostatic stabilization, restrain the growth of nanoparticle during the hydrolysis and reduction reactions, but also narrow size distribution and hydrophilic surface were obtained. The detail mechanism to synthesis of monodisperse magnetite nanoparticles was investigated. In the second part, we attached fluorescent carbon dots on magnetite nanoparticles. The results show that carbon dots/Fe3O4 nanocomposites can still have good fluorescence characteristics after synthesized. The cytotoxicity test results also confirmed low cytotoxicity of magnetite and nanocomposites. With magnetics in nanocomposites, it can provide more efficiency for bioimaging and biosensing in the future.