Study on Antioxidant Activity of Synthetic Chlorogenic Acid Derivatives
碩士 === 弘光科技大學 === 化妝品應用研究所 === 107 === The objectives of the present study were to chlorogenic acid derivatives ((E)-2-amino-3-((3-((3-(3,4-dihydroxyphenyl)acryloyl)oxy)-1,4,5-trihydroxycyclo hexanecarbonyl) thio) propanoic acid, CGAC) were synthesized by the esterification reaction of chlorogenic a...
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ndltd-TW-107HKU007930032019-08-22T04:01:07Z http://ndltd.ncl.edu.tw/handle/p87vj6 Study on Antioxidant Activity of Synthetic Chlorogenic Acid Derivatives 合成綠原酸酯化衍生物並對其探討抗氧化能力之研究 CHAN, YI-HSUAN 詹依璇 碩士 弘光科技大學 化妝品應用研究所 107 The objectives of the present study were to chlorogenic acid derivatives ((E)-2-amino-3-((3-((3-(3,4-dihydroxyphenyl)acryloyl)oxy)-1,4,5-trihydroxycyclo hexanecarbonyl) thio) propanoic acid, CGAC) were synthesized by the esterification reaction of chlorogenic acid and cysteine. Characterization of CGAC was performed by FTIR, 1H and 13C NMR spectroscopic methods analysis. Antioxidant activity of the CGAC was evaluated using DPPH, ABTS▪+, total phenolic content, β-carotene-linoleic acid assay. The whitening effects of CGAC by the activity of chelating ability Cu2+ power, and inhibitory activity of mushroom tyrosinase were studied. The results indicated: In the DPPH radical scavenging, the IC50 value of CGAC is 44.092 μM. In the ABTS▪+ reaction, the IC50 values of CGAC is 174.140 μM lower than positive controls (the IC50 values of ascorbic acid is 183.223 μM). the results of total phenolic content test, the CGAC total phenolic content 0.554 (μg of GAE/μg of substance) is less than chlorogenic acid content 0.636 (μg of GAE/μg of substance). In the Chelating ability Cu2+ power reaction, the CGAC showed stronger antioxidant activity than chlorogenic acid the effect is 2.44 factor of chlorogenic acid. The CGAC had favorable activity than chlorogenic acid in the β-carotene-linoleic acid assay. Therefore, the CGAC has been successfully synthesized and identified, and has better antioxidant activity. In the inhibition of mushroom tyrosinase test, chlorogenic acid and CGAC to be confirmed. CHOU, YI-CHEN 周怡真 2019 學位論文 ; thesis 104 zh-TW |
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碩士 === 弘光科技大學 === 化妝品應用研究所 === 107 === The objectives of the present study were to chlorogenic acid derivatives
((E)-2-amino-3-((3-((3-(3,4-dihydroxyphenyl)acryloyl)oxy)-1,4,5-trihydroxycyclo
hexanecarbonyl) thio) propanoic acid, CGAC) were synthesized by the esterification reaction of chlorogenic acid and cysteine. Characterization of CGAC was performed by FTIR, 1H and 13C NMR spectroscopic methods analysis. Antioxidant activity of the CGAC was evaluated using DPPH, ABTS▪+, total
phenolic content, β-carotene-linoleic acid assay. The whitening effects of CGAC
by the activity of chelating ability Cu2+ power, and inhibitory activity of
mushroom tyrosinase were studied. The results indicated: In the DPPH radical
scavenging, the IC50 value of CGAC is 44.092 μM. In the ABTS▪+ reaction, the
IC50 values of CGAC is 174.140 μM lower than positive controls (the IC50 values
of ascorbic acid is 183.223 μM). the results of total phenolic content test, the CGAC total phenolic content 0.554 (μg of GAE/μg of substance) is less than
chlorogenic acid content 0.636 (μg of GAE/μg of substance). In the Chelating
ability Cu2+ power reaction, the CGAC showed stronger antioxidant activity than
chlorogenic acid the effect is 2.44 factor of chlorogenic acid. The CGAC had
favorable activity than chlorogenic acid in the β-carotene-linoleic acid assay.
Therefore, the CGAC has been successfully synthesized and identified, and has
better antioxidant activity. In the inhibition of mushroom tyrosinase test,
chlorogenic acid and CGAC to be confirmed.
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author2 |
CHOU, YI-CHEN |
author_facet |
CHOU, YI-CHEN CHAN, YI-HSUAN 詹依璇 |
author |
CHAN, YI-HSUAN 詹依璇 |
spellingShingle |
CHAN, YI-HSUAN 詹依璇 Study on Antioxidant Activity of Synthetic Chlorogenic Acid Derivatives |
author_sort |
CHAN, YI-HSUAN |
title |
Study on Antioxidant Activity of Synthetic Chlorogenic Acid Derivatives |
title_short |
Study on Antioxidant Activity of Synthetic Chlorogenic Acid Derivatives |
title_full |
Study on Antioxidant Activity of Synthetic Chlorogenic Acid Derivatives |
title_fullStr |
Study on Antioxidant Activity of Synthetic Chlorogenic Acid Derivatives |
title_full_unstemmed |
Study on Antioxidant Activity of Synthetic Chlorogenic Acid Derivatives |
title_sort |
study on antioxidant activity of synthetic chlorogenic acid derivatives |
publishDate |
2019 |
url |
http://ndltd.ncl.edu.tw/handle/p87vj6 |
work_keys_str_mv |
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