1.Synthesis of C2-asymmetric Chiral Ether2.\"chiral ether-TiCl4-Mg\" promoted asymmetric coupling of CH2Cl2 with aldehyde and ketone

• Main Authors: Yu-Xieng Peng, 彭裕翔
• Other Authors: 楊圖信
• Format: Others
• Language: zh-TW
• Published: 2019
• Online Access: http://ndltd.ncl.edu.tw/handle/4ms5pn

碩士 === 國立中興大學 === 化學系所 === 107 === 　　Chiral ligand plays a key role in asymmetric catalytic reaction, and which that usually adopt C2 symmetry. Therefore, the objective of this thesis are development and catalyst effect investigation of C2 chiral ligand. We applied D-mannitol as initiator, it would form 1,4:3,6-dianhydro-D-mannitol after dehydrated, and we further synthesis and increase the efficiency of the reaction. 　　According to our previous study, the dihalomethane could Methylate with aldehydes or ketones generate halomethyltitanium compound under the present of TiCl4 and Mg complex. The reaction would differ from solvent and the ration of TiCl4 and Mg. Due to the product is single stereoceter, we attempt to initiate this reaction with chiral ether to change the result in this thesis.