The association between hospitalization infection incidence and autoimmune diseases in breast cancer patients after anti-cancer treatment.
博士 === 國立中興大學 === 轉譯醫學博士學位學程 === 107 === Purpose: To evaluate the infection incidence in breast cancer patients whether they have a major autoimmune disease or not. Methods: This retrospective cohort study compared the infection incidence of 174 breast cancer patients with an autoimmune disease, inc...
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ndltd-TW-107NCHU53250012019-11-30T06:09:40Z http://ndltd.ncl.edu.tw/cgi-bin/gs32/gsweb.cgi/login?o=dnclcdr&s=id=%22107NCHU5325001%22.&searchmode=basic The association between hospitalization infection incidence and autoimmune diseases in breast cancer patients after anti-cancer treatment. 乳癌病人經抗癌治療後之住院感染發生率與自體免疫疾病之相關聯性 Chien-Chih Chen 陳建志 博士 國立中興大學 轉譯醫學博士學位學程 107 Purpose: To evaluate the infection incidence in breast cancer patients whether they have a major autoimmune disease or not. Methods: This retrospective cohort study compared the infection incidence of 174 breast cancer patients with an autoimmune disease, including Sjogren’s Syndrome (SS), Rheumatoid Arthritis (RA), and Systemic Lupus Erythematosus (SLE), along with 4429 patients without an autoimmune disease, for the period 2000 to 2016. Six-hundred and ninety six, age-, stage-, and diagnosis era-matched patients without any autoimmune disease were analyzed to eliminate the effects of these confounding factors may have on the results. Results: After adjusting for age, stage and diagnosis era, breast cancer patients with an autoimmune disease had a higher Infection Incidence Ratio (IRR: 2.62) than the patients without any autoimmune disease. In the univariate analysis, patients who had an autoimmune disease (p <0.001), underwent chemotherapy (p <0.001), radiotherapy (p=0.004), and monoclonal antibody therapy (p <0.001) had a higher infection rate. In the multivariate analysis, autoimmune disease was shown to be an independent factor for infection incidence. Conclusion: Autoimmune disease was a potential predictor of infection incidence in breast cancer patients post-treatment after adjusting for clinical confounding factors. Meei-Ling Sheu Hsin-Hua Chen 許美鈴 陳信華 2019 學位論文 ; thesis 100 zh-TW |
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博士 === 國立中興大學 === 轉譯醫學博士學位學程 === 107 === Purpose: To evaluate the infection incidence in breast cancer patients whether they have a major autoimmune disease or not.
Methods: This retrospective cohort study compared the infection incidence of 174 breast cancer patients with an autoimmune disease, including Sjogren’s Syndrome (SS), Rheumatoid Arthritis (RA), and Systemic Lupus Erythematosus (SLE), along with 4429 patients without an autoimmune disease, for the period 2000 to 2016. Six-hundred and ninety six, age-, stage-, and diagnosis era-matched patients without any autoimmune disease were analyzed to eliminate the effects of these confounding factors may have on the results.
Results: After adjusting for age, stage and diagnosis era, breast cancer patients with an autoimmune disease had a higher Infection Incidence Ratio (IRR: 2.62) than the patients without any autoimmune disease. In the univariate analysis, patients who had an autoimmune disease (p <0.001), underwent chemotherapy (p <0.001), radiotherapy (p=0.004), and monoclonal antibody therapy (p <0.001) had a higher infection rate. In the multivariate analysis, autoimmune disease was shown to be an independent factor for infection incidence.
Conclusion: Autoimmune disease was a potential predictor of infection incidence in breast cancer patients post-treatment after adjusting for clinical confounding factors.
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Meei-Ling Sheu |
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Meei-Ling Sheu Chien-Chih Chen 陳建志 |
author |
Chien-Chih Chen 陳建志 |
spellingShingle |
Chien-Chih Chen 陳建志 The association between hospitalization infection incidence and autoimmune diseases in breast cancer patients after anti-cancer treatment. |
author_sort |
Chien-Chih Chen |
title |
The association between hospitalization infection incidence and autoimmune diseases in breast cancer patients after anti-cancer treatment. |
title_short |
The association between hospitalization infection incidence and autoimmune diseases in breast cancer patients after anti-cancer treatment. |
title_full |
The association between hospitalization infection incidence and autoimmune diseases in breast cancer patients after anti-cancer treatment. |
title_fullStr |
The association between hospitalization infection incidence and autoimmune diseases in breast cancer patients after anti-cancer treatment. |
title_full_unstemmed |
The association between hospitalization infection incidence and autoimmune diseases in breast cancer patients after anti-cancer treatment. |
title_sort |
association between hospitalization infection incidence and autoimmune diseases in breast cancer patients after anti-cancer treatment. |
publishDate |
2019 |
url |
http://ndltd.ncl.edu.tw/cgi-bin/gs32/gsweb.cgi/login?o=dnclcdr&s=id=%22107NCHU5325001%22.&searchmode=basic |
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