| Summary: | 碩士 === 國立交通大學 === 分子醫學與生物工程研究所 === 107 === Chronic Kidney Disease (CKD) affects 11.9% of adult population in Taiwan. CKD not only affects people's health but also costs large amount of money to provide CKD patient medical resources from the national government. Other complications are problems that can happen with CKD patient such as diabetes, hypertension, and cardiovascular diseases, etc. These complications can lead to a rapid deterioration of the disease and the depletion of existing medical resources. Therefore, early diagnosis and prevention of CKD become more important.
In recent years, studies have pointed out that the microbial flora of the intestine is closely related to many diseases. The microbial flora of the intestine is not only co-evolved with humans, but also can affect the health of humans, synthesis of the body's metabolites, inhibition of intestinal pathogens, and reduce the toxicity of toxic substances on the human body has established a good immune system. But not all bacteria are beneficial to humans. Some anaerobic bacteria break down the metabolites of protein synthesis in the intestine but are toxic to humans. Previous studies have confirmed that derivatives of bacterial metabolites, "indoxyl sulfate" are highly accumulated in the blood of patients with chronic kidney disease, and are toxic to vascular cells, accelerating the deterioration of renal function.
Therefore, it is more important to evaluate the amount of Indole. By searching for the bacteria that produce Indoxyl-sulfate to design a detection kit, develop a method to evaluate the ability of bacteria to produce Indole to detect the condition of end-stage chronic kidney patients, hoping to be in CKD patients found representative bacteria. It is expected that by changing the intestinal flora and significantly slow down the development of chronic kidney disease and effectively improve the health status of patients.
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