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碩士 === 國立中央大學 === 化學學系 === 107 === The enantioselective organocatalytic aza-Michael addition of 2-hydroxypyridines (pyridin-2(1H)-ones) to a,b-unsaturated 1,4-diones to yield chiral N-substituted 2-pyridones is reported. The reactions were optimized by the choice of solvents and screening a series o...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Others |
| Language: | zh-TW |
| Published: |
2019
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| Online Access: | http://ndltd.ncl.edu.tw/handle/3rh6k3 |
| Summary: | 碩士 === 國立中央大學 === 化學學系 === 107 === The enantioselective organocatalytic aza-Michael addition of 2-hydroxypyridines (pyridin-2(1H)-ones) to a,b-unsaturated 1,4-diones to yield chiral N-substituted 2-pyridones is reported. The reactions were optimized by the choice of solvents and screening a series of cinchonine catalysts to achieve good yields and enantioselectivities (up to 98% yield and >99% ee). Finally using Michael product completed the synthesis to precursor of Human Rhinovirus 3C Protease Inhibitors through a series of reaction.
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