Non-invasive multi-wavelength optical blood glucose detection and application

• Main Authors: JIA-YAN LAN, 藍嘉彥
• Other Authors: Ching-Jung Chuang
• Format: Others
• Language: zh-TW
• Published: 2019
• Online Access: http://ndltd.ncl.edu.tw/handle/s6nh4a

碩士 === 國立東華大學 === 光電工程學系 === 107 === This research uses a principle that polarized light rotates through the chiral structure to design a non-invasive blood glucose measurement method. This method can achieve fast and non-invasive blood glucose measurement. We find the dispersion relationship between different wavelengths and deflection angles through the linear relationship between the concentration of the chiral structure and the deflection angle. It is found in the literature that the amount of optical rotation is inversely proportional to the square of the wavelength, and is related to two coefficients, respectively coefficient (A), dispersion coefficient (λ0), through the results of repeated measurements, we get the values of both. In the case of 10% by weight and 1dm of optical path, the optical rotation coefficient we measured is 1.8401×10^6 and the dispersion coefficient is 172.4±1. At the same time, solve the problem of standard samples lacking 0% of human blood glucose concentration, we designed a multi-wavelength angle discrimination method to get the difference angle by using two wavelengths of 660nm and 407nm, and to use the relationship between wavelength and the amount of optical rotation and linear relationship between the optical rotation coefficient and concentration to gives a precise concentration value. In order to prove the reliability of the system, the measurement of 10%, 5%, 3%, 2%, 1% glucose solution, from the experimental results can prove that the error of this non-invasive blood glucose measurement is about 4%. The normal person is blood sugar after meals is about (140mg/dL-200mg/dL), the accuracy of this method is about 12mg/dL, which is enough to judge the normality of blood glucose concentration. This research has developed a new non-invasive blood glucose measurement method that can quickly and accurately measure blood glucose concentration, and through experiments, the accuracy of this system is sufficient to judge the normality of blood glucose, is a very potential non-invasive measurement method.