| Summary: | 碩士 === 國防醫學院 === 公共衛生學研究所 === 107 === Background:
Metabolic syndrome (MetS) constitutes a cluster of metabolic and cardiovascular abnormalities, and it becomes critical public health issues worldwide. Recent studies have shown that circadian system disarrangement and sleep disorders are risk factors for the development of metabolic syndrome. It was reported that genetic polymorphisms in the circadian-related genes are associated with MetS. In addition, melatonin plays a role in the biologic regulation of circadian rhythms and there are evidences for therapeutic use of melatonin in human MetS. However, there is currently limited research on the interaction of melatonin and genetic polymorphisms in the circadian-related genes in the risk of MetS.
Objective:
The aim of this study is to investigate the independent and interactive relationships of polymorphisms in the circadian-related genes and melatonin with the risk of MetS.
Methods:
This is a case-control study conducted at the Show-Chwan Memorial Hospital in the Changhua area. A total of 273 patients with MetS and 730 matched controls were included in the study. All participants received a set of standardized questionnaire interview, physical examinations and blood sampling. Melatonin concentrations were determined using IBL Melatonin ELISA kit. Genotyping was performed by TaqMan OpenArray Genotyping Plates. The logistic regression model was used to analyze the associations of melatonin concentrations, circadian-related gene polymorphisms and MetS.
Results:
This study shows that melatonin has a modification effect on the association between polymorphisms in the circadian-related genes and MetS and its components. However, some of these modification effects are different from the results in the previous studies. Hence, in the future, it is needed to investigate the pathways and mechanisms on the modification effect of melatonin on the association between polymorphisms in the circadian-related genes and MetS.
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