Studies on the Constituents of the root of Pseudostellaria heterophylla (Miq.) Pax ex Pax et Hoffm.

• Main Authors: LIN, PENG-WEI, 林芃緯
• Other Authors: CHANG, WEN-LIANG
• Format: Others
• Language: zh-TW
• Published: 2019
• Online Access: http://ndltd.ncl.edu.tw/handle/7ng82j

碩士 === 國防醫學院 === 藥學研究所 === 107 === Pseudostellaria heterophylla (Miq.) Pax ex Pax et Hoffm. is a perennial plant of the Caryophyllaceae family, Pseudostellaria genus, known commonly as Hai Er Shen (Kid Ginseng), Tai Zi Shen (Prince Ginseng). It is mainly distributed in China, Japan and Korea, and is now mostly cultivated. The root of P. heterophylla possessed anti-hyperglycemic, immunostimulant, promoting glucose consumption, anti-tumor, anti-fatigue, anti-tussive, anti-oxidative damage and anti-melanin activities. The aim of this study is separated the water-soluble and alcohol-soluble compounds of the root of P. heterophylla. In order to explore the active compounds, the extracts of P. heterophylla were subjected to reversed-phase chromatography to yield five compounds: Four known compounds and one new compound (CP331) were isolated from the extracts of P. heterophylla. These known compounds were identified as one nucleoside: adenosine (1), one benzoic acid derivative: p-hydroxybenzoic acid (2), one cyclic peptide: pseudostellarin A (3), one fatty acid: linoleic acid (4) by comparing their spectroscopic data with those reported in the literature and one furan derivative: CP331 (5). Among them, compound 5 is a new compound and compound 2 was isolated from this plant for the first time. The yield of compound 3 is 2.81×10-4% and displays anti-melanin activity has been found. Other pharmacological activities can be explored in the future.