Brain structural change of Alzheimer’s Disease: a longitudinal analysis at 3T

• Main Authors: Yu-Che Hung, 洪昱哲
• Other Authors: Tzu Chao,Chuang
• Format: Others
• Language: zh-TW
• Published: 2019
• Online Access: http://ndltd.ncl.edu.tw/handle/s764d6

碩士 === 國立中山大學 === 電機工程學系研究所 === 107 === Alzheimer''s disease is usually declined in memory and atrophy in the structure of the brain. The hippocampal volume and the medial temporal cortex atrophy are the best known. In addition, patients are found atrophy in the posterior part of the brain, such as parietal lobe and Posterior cingulate. The course of Alzheimer''s disease is slow and irreversible. Therefore, the long-term follow-up analysis can be used to observe the development curve of subjects in different course of disease. However, the long-term tracking data collection takes a lot of time, so some scholars have passed a large number of The method of collecting data is aggregated into an open source, ADNI, for use by researchers interested in Alzheimer''s disease. This study used a linear mixed effects model proposed by Jorge L. Bernal-Rusiel et al. in 2013, using ADNI''s 1.5T data, and using this model to longitudinal study of the hippocampal volume and the entorhinal cortical thickness in the medial temporal cortex. The results showed that in the hippocampus volume fraction, patients of Alzheimer''s disease showed significant differences compared with normal control subjects and mild cognitive impairment. While in the entorhinal cortical thickness, patients of Alzheimer''s disease has degree of difference in patients with mild cognitive impairment. This study used a mixed linear model to perform longitudinal study, and analysis 3T MRI included normal control, mild cognitive impairment, and patients of Alzheimer''s disease from ADNI''s.Besides of analyzing of hippocampal volume and entorhinal cortical thickness, also included parahippocampal gyrus, fusiform gyrus, parietal lobe: inferior parietal lobule, postcentral gyrus, superior parietal lobule, supramarginal gyrus, and posterior cingulate and isthmus cingulate regions of the temporal cortex. The results showed that in the hippocampal volume and medial temporal cortex, Alzheimer''s disease had significant differences compared with mild cognitive impairment and normal control subjects, while in the parietal lobe and posterior cingulate and isthmus cingulate, a more consistent atrophy trend was not observed as expected, and even in the results of partial-partitioned mild cognitive impairment subjects showed a trend of increasing over year . Interceptors with Alzheimer''s disease are even larger than subjects with mild cognitive impairment or normal control.