Development of A Microfluidic Device Integrated with A LC-MS/MS System for Detecting Psychoactive Substance

• Main Authors: Pei-Zhen Chen, 陳姵蓁
• Other Authors: Pin-Chuan Chen
• Format: Others
• Language: zh-TW
• Published: 2019
• Online Access: http://ndltd.ncl.edu.tw/handle/5tx286

碩士 === 國立臺灣科技大學 === 機械工程系 === 107 === How to rapidly analyze the drug compound is an emerging demand and this study intends to integrate a microfluidic chip with a LC-MS/MS system to address this issue. Since the operation pressure of compound separation in a microchannel is relatively high and how to completely seal the separation particle inside the microchannel is quite difficult, chip manufacturing is quite challenging. Two approaches were used, (1) ethanol solution and wall structure with UV glue were used to bond the chip with securing the particles inside the microchannel; (2) C-type fixture was used to increase the bonding strength. Initial experiment result showed that this chip with filled particles can be potentially used as a commercial separation column for analyzing the drug compound with connecting to a LC-MS/MS system.