Surfactant-free synthesis of mesoporous bioactive glass using spray pyrolysis for drug delivery

• Main Authors: Jung-Ting Sun, 孫榮廷
• Other Authors: Shao-Ju Shih
• Format: Others
• Language: zh-TW
• Published: 2019
• Online Access: http://ndltd.ncl.edu.tw/handle/u2h694

碩士 === 國立臺灣科技大學 === 材料科學與工程系 === 107 === With the development of science and technology and medical care, the average life expectancy of the world's population has prolonged, the problems faced by the aging population have gradually emerged. With age, the normal aging process will lead to the degradation of various physiological functions. According to statistics, the fall of the elderly is the second leading cause of accidental injuries. Fractures caused by falls or head trauma will increase the risk of infection and illness. According to reports, among the patients with diabetes in Taiwan, the elderly account for more than 40%, and the wound healing ability of diabetic patients is low. At this time, if the old man falls and fractures and wounds, and he has diabetes, it will be easy to be infected during surgery. It is an inflammatory reaction, but it is life-threatening. The resilience of the elderly is poor, and Mesoporous Bioactive glass (MBG) is biologically active and can carry drugs in its pores. When the drug-loaded MBG is placed in the human body, it will produce hydrogen and oxygen on the surface of the material. Hydroxyapatite (HA) can effectively help bone repair, and the loaded drug can reduce the chance of bacterial infection. It is a good biomedical and drug carrier material. In this study, spray pyrolysis (SP) and different concentrations of formic acid, acetic acid and lactic acid were added as pore-forming agents to prepare high specific surface area mesoporous bioactive glass. Increasing the specific surface area not only improved biological activity, but also increased drug load. the amount. The results of this study show that MBG with high specific surface area has high bioactivity and high drug release.