Study of Tungsten Trioxide and Tungsten Trioxide Hydrate Nanoparticles on Lung Cytotoxicity
碩士 === 國立虎尾科技大學 === 生物科技系碩士班 === 107 === In this experiment, tungsten trioxide (WO3) was modified to synthesize tungsten trioxide hydrate (WO3·H2O). The lung cytotoxicity test of WO3 and WO3·H2O will be evaluated in this study and its mechanism will be explored. Results indicated that WO3 and WO3·H2...
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| Format: | Others |
| Language: | zh-TW |
| Published: |
2019
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| Online Access: | http://ndltd.ncl.edu.tw/handle/353752 |
| Summary: | 碩士 === 國立虎尾科技大學 === 生物科技系碩士班 === 107 === In this experiment, tungsten trioxide (WO3) was modified to synthesize tungsten trioxide hydrate (WO3·H2O). The lung cytotoxicity test of WO3 and WO3·H2O will be evaluated in this study and its mechanism will be explored. Results indicated that WO3 and WO3·H2O induced significant decreases in cell viability (<86% of control) and significant increases in LDH leakage (>110% of control) after 24 hr exposure. Both of the materials reduced the expression of HO-1 (0.15-0.33 folds of control) and SOD-2 (0.31-0.66 folds of control) that increased the production of proinflammatory cytokins (1.6-2.3 folds of control) as well as decrease SERPINA-1 expression (0.28-0.58 fold of control). The results show that WO3·H2O has lower toxicity than WO3. This study proves that the modified WO3 reduce its toxicity and show the development potential of WO3·H2O in future applications.
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