Factors Associated with Long-term Proton Pump Inhibitors Use in Patients with Gastroesophageal Reflux Disease

• Main Authors: Jhuo, Ciao-Min, 卓巧敏
• Other Authors: Wen, Shu-Hui
• Format: Others
• Language: zh-TW
• Published: 2019
• Online Access: http://ndltd.ncl.edu.tw/handle/38rp5t

碩士 === 慈濟大學 === 公共衛生學系碩士班 === 107 === Background: Proton pump inhibitors (PPIs) are effective drugs of anti-reflux treatment and are extensively prescribed to suppress gastric acid secretion in gastroesophageal reflux disease (GERD) patients. Recently, potential adverse effects associated with long-term PPI use were reported. We aim to evaluate the associations between patient characteristics and long-term use of PPIs. Method: We conducted a prospective cohort study and recruited adult GERD patients received PPIs treatment from February 2016 to February 2018. Long-term users (n=97, 21%) were defined as patients received over 4 months of PPI treatment, whereas those patients received less than 4 months of PPI treatment were short-term users (n=370, 79%). We collected detailed baseline information including questionnaires of demographic characteristics, GERD symptoms, quality of life , sleeping quality, anxiety, and depression. Stepwise logistic regression analyses were employed to identify factors related to long-term PPI use. Results: Compared to short-term PPI users, long-term users had higher proportion of GERD history between 2-5 years (40.0% vs. 16.7%, p<0.001), lower GERD-related symptom scores (9.22 vs. 11.14, p=0.033), and depression score (9.25 vs. 11.64, p=0.021). Based on logistic regression analysis, patients with GERD history between 2-5 years had a greater OR of long-term use (p<0.001) compared to those with GERD < 2 years. When limited to patients with GERD history > 2 years, older age and larger BMI were associated with greater odds of using PPI over 4 months. Conclusions: Our study found that GERD history between 2-5 years was associated with higher odds of long-term users, especially for patients with older age and greater BMI.