One-pot Reaction for the Synthesis of Flavones via Oxidation of Flavanones and Selective Suzuki-Miyaura Reaction to 3- and 4-Bromocoumarins Catalyzed by Water-soluble Palladium Catalyst
碩士 === 國立臺北科技大學 === 分子科學與工程系有機高分子碩士班 === 107 === The dissertation comprises two subjects. In the first subject, we designed a Pd(OAc)2/cationic 2,2’-bipyridyl-catalytic system to catalyzed conjugate addition of chromones and arylboronic acids forming flavanone derivatives as the first step of one-po...
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ndltd-TW-107TIT0031A0622019-11-06T03:33:16Z http://ndltd.ncl.edu.tw/handle/hews7c One-pot Reaction for the Synthesis of Flavones via Oxidation of Flavanones and Selective Suzuki-Miyaura Reaction to 3- and 4-Bromocoumarins Catalyzed by Water-soluble Palladium Catalyst 水溶性鈀觸媒進行一鍋黃烷酮氧化反應合成黃酮及具選擇性的3-和4-溴香豆素的 Suzuki-Miyaura 反應 HUNG, YING-CHI 洪英棋 碩士 國立臺北科技大學 分子科學與工程系有機高分子碩士班 107 The dissertation comprises two subjects. In the first subject, we designed a Pd(OAc)2/cationic 2,2’-bipyridyl-catalytic system to catalyzed conjugate addition of chromones and arylboronic acids forming flavanone derivatives as the first step of one-pot reaction, in second step adding iodine which undergoes oxidation of flavanone to obtain flavone product. Then the foregoing flavone derivatives proceeded with demethylation to acquire flavone nature products and medical potential flavone derivatives. In the second subject, our research was aimed to exploit water-soluble palladium catalyst to conduct selective Suzuki-Miyaura reaction of 3- and 4-bromocoumarins and arylboronic acids in water through different temperatures and bases. Next we carried out asymmetric Suzuki-Miyaura reaction to 3.4-dibromocoumarin by one-pot reaction in water and thereby gaining various coumarin derivatives. TSAI, FU-YU 蔡福裕 2019 學位論文 ; thesis 206 zh-TW |
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碩士 === 國立臺北科技大學 === 分子科學與工程系有機高分子碩士班 === 107 === The dissertation comprises two subjects. In the first subject, we designed a Pd(OAc)2/cationic 2,2’-bipyridyl-catalytic system to catalyzed conjugate addition of chromones and arylboronic acids forming flavanone derivatives as the first step of one-pot reaction, in second step adding iodine which undergoes oxidation of flavanone to obtain flavone product. Then the foregoing flavone derivatives proceeded with demethylation to acquire flavone nature products and medical potential flavone derivatives.
In the second subject, our research was aimed to exploit water-soluble palladium catalyst to conduct selective Suzuki-Miyaura reaction of 3- and 4-bromocoumarins and arylboronic acids in water through different temperatures and bases. Next we carried out asymmetric Suzuki-Miyaura reaction to 3.4-dibromocoumarin by one-pot reaction in water and thereby gaining various coumarin derivatives.
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author2 |
TSAI, FU-YU |
author_facet |
TSAI, FU-YU HUNG, YING-CHI 洪英棋 |
author |
HUNG, YING-CHI 洪英棋 |
spellingShingle |
HUNG, YING-CHI 洪英棋 One-pot Reaction for the Synthesis of Flavones via Oxidation of Flavanones and Selective Suzuki-Miyaura Reaction to 3- and 4-Bromocoumarins Catalyzed by Water-soluble Palladium Catalyst |
author_sort |
HUNG, YING-CHI |
title |
One-pot Reaction for the Synthesis of Flavones via Oxidation of Flavanones and Selective Suzuki-Miyaura Reaction to 3- and 4-Bromocoumarins Catalyzed by Water-soluble Palladium Catalyst |
title_short |
One-pot Reaction for the Synthesis of Flavones via Oxidation of Flavanones and Selective Suzuki-Miyaura Reaction to 3- and 4-Bromocoumarins Catalyzed by Water-soluble Palladium Catalyst |
title_full |
One-pot Reaction for the Synthesis of Flavones via Oxidation of Flavanones and Selective Suzuki-Miyaura Reaction to 3- and 4-Bromocoumarins Catalyzed by Water-soluble Palladium Catalyst |
title_fullStr |
One-pot Reaction for the Synthesis of Flavones via Oxidation of Flavanones and Selective Suzuki-Miyaura Reaction to 3- and 4-Bromocoumarins Catalyzed by Water-soluble Palladium Catalyst |
title_full_unstemmed |
One-pot Reaction for the Synthesis of Flavones via Oxidation of Flavanones and Selective Suzuki-Miyaura Reaction to 3- and 4-Bromocoumarins Catalyzed by Water-soluble Palladium Catalyst |
title_sort |
one-pot reaction for the synthesis of flavones via oxidation of flavanones and selective suzuki-miyaura reaction to 3- and 4-bromocoumarins catalyzed by water-soluble palladium catalyst |
publishDate |
2019 |
url |
http://ndltd.ncl.edu.tw/handle/hews7c |
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