Preparation and Characterization of Curcumin Self-microemulsifying Drug Delivery System
碩士 === 大同大學 === 生物工程學系(所) === 107 === Curcumin is an orange-yellow powder with pharmacological properties such as hypolipidemic, anti-oxidant, anti-inflammatory and anti-atherosclerotic arteriosclerosis. However, curcumin is a lipophilic polyphenolic substance that is extremely poorly soluble in wat...
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ndltd-TW-107TTU051060082019-11-05T03:37:54Z http://ndltd.ncl.edu.tw/handle/tad45b Preparation and Characterization of Curcumin Self-microemulsifying Drug Delivery System 薑黃素自微乳化給藥系統的製備及其特性研究 Yu-bu Lin 林于卜 碩士 大同大學 生物工程學系(所) 107 Curcumin is an orange-yellow powder with pharmacological properties such as hypolipidemic, anti-oxidant, anti-inflammatory and anti-atherosclerotic arteriosclerosis. However, curcumin is a lipophilic polyphenolic substance that is extremely poorly soluble in water and easy to decompose under alkaline conditions. It will be quickly metabolized into inactive products and excreted in the body after entering the body. Therefore, curcumin, not be absorbed when it is ingested alone, greatly reduces the effect for human health. Self-microemulsifying drug delivery system (SMEDDS) is a drug delivery system consisting of oil phase, surfactant, and co-surfactant. It can enhance the solubility of poorly soluble drugs. The improvement for the absorption rate and bioavailability of drugs are a new type of drug carrier technology in recent years. With the aid of the surfactant and the co-surfactant, the oil and the hydrophobic substance can be completely dispersed to form a clear and transparent emulsion with a small particle size. At first, the microemulsion is prepared by using oleic acid as the oil phase, tween 20 as the surfactant, transcutol, dissolving curcumin, as the co-surfactant, and water. Tween 20 was mixed with oleic acid/transcutol (1:2) in different proportions, and then water was added until to turbid in solution to make a pseudo-three-phase diagram. Microcrystalline cellulose, capable of adsorbing liquid and oil, is added, and dried at 60C for 48hr to prepare curcumin self-microemulsifying powder. The dissolving speeds of curcumin solid microemulsion were tested in different dilution volumes of water. The results showed that the curcumin microemulsion powder, diluted 200 times with water, the adsorbent was disintegrated rapidly into liquid state and its dissolving speed was the best. This self-microemulsifying drug delivery system can greatly improve the solubility and bioavailability of curcumin. Ming-Tse Lin 林銘澤 2019 學位論文 ; thesis 38 zh-TW |
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碩士 === 大同大學 === 生物工程學系(所) === 107 === Curcumin is an orange-yellow powder with pharmacological properties such as hypolipidemic, anti-oxidant, anti-inflammatory and anti-atherosclerotic arteriosclerosis. However, curcumin is a lipophilic polyphenolic substance that is extremely poorly soluble in water and easy to decompose under alkaline conditions. It will be quickly metabolized into inactive products and excreted in the body after entering the body. Therefore, curcumin, not be absorbed when it is ingested alone, greatly reduces the effect for human health.
Self-microemulsifying drug delivery system (SMEDDS) is a drug delivery system consisting of oil phase, surfactant, and co-surfactant. It can enhance the solubility of poorly soluble drugs. The improvement for the absorption rate and bioavailability of drugs are a new type of drug carrier technology in recent years. With the aid of the surfactant and the co-surfactant, the oil and the hydrophobic substance can be completely dispersed to form a clear and transparent emulsion with a small particle size.
At first, the microemulsion is prepared by using oleic acid as the oil phase, tween 20 as the surfactant, transcutol, dissolving curcumin, as the co-surfactant, and water. Tween 20 was mixed with oleic acid/transcutol (1:2) in different proportions, and then water was added until to turbid in solution to make a pseudo-three-phase diagram. Microcrystalline cellulose, capable of adsorbing liquid and oil, is added, and dried at 60C for 48hr to prepare curcumin self-microemulsifying powder. The dissolving speeds of curcumin solid microemulsion were tested in different dilution volumes of water. The results showed that the curcumin microemulsion powder, diluted 200 times with water, the adsorbent was disintegrated rapidly into liquid state and its dissolving speed was the best. This self-microemulsifying drug delivery system can greatly improve the solubility and bioavailability of curcumin.
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author2 |
Ming-Tse Lin |
author_facet |
Ming-Tse Lin Yu-bu Lin 林于卜 |
author |
Yu-bu Lin 林于卜 |
spellingShingle |
Yu-bu Lin 林于卜 Preparation and Characterization of Curcumin Self-microemulsifying Drug Delivery System |
author_sort |
Yu-bu Lin |
title |
Preparation and Characterization of Curcumin Self-microemulsifying Drug Delivery System |
title_short |
Preparation and Characterization of Curcumin Self-microemulsifying Drug Delivery System |
title_full |
Preparation and Characterization of Curcumin Self-microemulsifying Drug Delivery System |
title_fullStr |
Preparation and Characterization of Curcumin Self-microemulsifying Drug Delivery System |
title_full_unstemmed |
Preparation and Characterization of Curcumin Self-microemulsifying Drug Delivery System |
title_sort |
preparation and characterization of curcumin self-microemulsifying drug delivery system |
publishDate |
2019 |
url |
http://ndltd.ncl.edu.tw/handle/tad45b |
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