The components of Hericium erinaceus mycelium ameliorate Alzheimer’s disease-related pathologies in metabolically stressed APP/PS1 mice

• Main Authors: Kuan-Wei Wu, 伍冠維
• Other Authors: Young-Ji Shiao
• Format: Others
• Language: zh-TW
• Published: 2019
• Online Access: http://ndltd.ncl.edu.tw/handle/a7zz6d

碩士 === 國立陽明大學 === 生物藥學研究所 === 107 === Alzheimer's disease (AD) is a neurodegenerative disease and the most common type of dementia, and metabolic syndrome is regarded as one of the risk factors for AD pathogenesis. In our previous study, we have successfully established a metabolically stressed AD animal model (HFSTZ-APP/PS1) by treating APP/PS1 transgenic mice with high-fat diet and a low-dose injection of Streptozotocin (STZ). Aβ burden, glia activation, and neuroinflammation are exacerbated in HFSTZ-APP/PS1 mice. On the other hand, our previous studies have shown that Hericium erinaceus mycelia (HE-My) and its components, Erinacine A (HE-A) attenuated cerebral Aβ burden, reduced the number of plaque-associated glia activation, promoted hippocampal neurogenesis, ameliorated the ability of nesting behavior, elevated the level of insulin-degrading enzyme (IDE) and nerve growth factor (NGF). Therefore, the aim of this study is to examine the effects of HE-A、Erinacine C (HE-C) and Erinacine S (HE-S) on the AD-related pathological changes in HFSTZ-APP/PS1 mice. We found that (1) HE-A, HE-C and HE-S did not affect body weight, fasting glucose, and oral glucose tolerance test in HFSTZ-APP/PS1 mice; (2) Three erinacines significantly ameliorated the ability of nesting behavior; (3) Three erinacines significantly attenuated cerebral Aβ burden and reduced the number of plaque-associated glia activation; (4) Three erinacines, especially HE-A and HE-C, significantly promoted hippocampal neurogenesis in HFSTZ-APP/PS1 mice. In summary, the components of Hericium erinaceus mycelia including HE-A, HE-C and HE-S can improve the AD-related pathology in HFSTZ-APP/PS1 mice. The activity is not mediated by the risk factor, metabolic syndrome.