Hepatic biotransformation of lithocholic acid : role of cytochrome P450 enzymes
The purpose of the present study was to investigate the in vitro biotransformation of lithocholic acid (3α-hydroxy-5β-cholanoic acid, LCA). A validated and optimized method to analyze metabolite formation was developed using liquid chromatography-electrospray mass spectrometry (LC/MS). LCA (0.5-300...
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| Language: | English |
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2010
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| Online Access: | http://hdl.handle.net/2429/17658 |