Methylenecyclohexane annulations : total syntheses of axane-type sesquiterpenoids
This thesis describes the preparation of 5-chloro-2-trimethyl-stannyl-1-pentene (111) and its conversion into 5-chloro-2-lithio-1-pentene (112). The latter reagent, which reacts smoothly with cyclohex-anone at -78°C to give 5-chloro-2-(1-hydroxycyclohexyl)-1-pentene (132), was found to be thermally...
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| Language: | English |
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University of British Columbia
2010
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| Online Access: | http://hdl.handle.net/2429/27655 |