Synthesis of 2:3-benzo-1, 1-dimethyl-1-silacyclohex-2-ene and derivatives
The synthesis of 2:3-benzo-1,1-dimethyl-1-silacyclo-hex-2-ene has been reported. This compound was prepared by the simultaneous addition of 3-(o-bromophenyl)-propyl bromide and dichlorodimethylsilane to excess magnesium in tetra-hydrofuran. The six-membered ring organosilicon compound was readily br...
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| Language: | English |
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University of British Columbia
2011
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| Online Access: | http://hdl.handle.net/2429/36704 |
| Summary: | The synthesis of 2:3-benzo-1,1-dimethyl-1-silacyclo-hex-2-ene has been reported. This compound was prepared by the simultaneous addition of 3-(o-bromophenyl)-propyl bromide and dichlorodimethylsilane to excess magnesium in tetra-hydrofuran. The six-membered ring organosilicon compound was readily brominated by N-bromosuccinimide to give the 4-derivative. Attempts were then made to synthesize the 4-cyano and the 4-carboxylate derivatives from this bromination product. Experimental data are also given for an attempted preparation of 2:3-benzo-4-(2-dimethylaminoethoxy)-1,1-dimethyl-1-silacyclohex-2-ene. === Pharmaceutical Sciences, Faculty of === Graduate |
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