Synthesis of 2:3-benzo-1, 1-dimethyl-1-silacyclohex-2-ene and derivatives

Synthesis of 2:3-benzo-1, 1-dimethyl-1-silacyclohex-2-ene and derivatives

The synthesis of 2:3-benzo-1,1-dimethyl-1-silacyclo-hex-2-ene has been reported. This compound was prepared by the simultaneous addition of 3-(o-bromophenyl)-propyl bromide and dichlorodimethylsilane to excess magnesium in tetra-hydrofuran. The six-membered ring organosilicon compound was readily br...

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Main Author: Lo, Daniel Ching-Shun
Language:English
Published: University of British Columbia 2011
Subjects:
Silicon compounds
Organic compounds > Synthesis
Online Access:http://hdl.handle.net/2429/36704
id ndltd-UBC-oai-circle.library.ubc.ca-2429-36704
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spelling ndltd-UBC-oai-circle.library.ubc.ca-2429-367042018-01-05T17:48:34Z Synthesis of 2:3-benzo-1, 1-dimethyl-1-silacyclohex-2-ene and derivatives Lo, Daniel Ching-Shun Silicon compounds Organic compounds -- Synthesis The synthesis of 2:3-benzo-1,1-dimethyl-1-silacyclo-hex-2-ene has been reported. This compound was prepared by the simultaneous addition of 3-(o-bromophenyl)-propyl bromide and dichlorodimethylsilane to excess magnesium in tetra-hydrofuran. The six-membered ring organosilicon compound was readily brominated by N-bromosuccinimide to give the 4-derivative. Attempts were then made to synthesize the 4-cyano and the 4-carboxylate derivatives from this bromination product. Experimental data are also given for an attempted preparation of 2:3-benzo-4-(2-dimethylaminoethoxy)-1,1-dimethyl-1-silacyclohex-2-ene. Pharmaceutical Sciences, Faculty of Graduate 2011-08-16T21:49:09Z 2011-08-16T21:49:09Z 1966 Text Thesis/Dissertation http://hdl.handle.net/2429/36704 eng For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use. University of British Columbia
collection NDLTD
language English
sources NDLTD
topic Silicon compounds
Organic compounds -- Synthesis
spellingShingle Silicon compounds
Organic compounds -- Synthesis
Lo, Daniel Ching-Shun
Synthesis of 2:3-benzo-1, 1-dimethyl-1-silacyclohex-2-ene and derivatives
description The synthesis of 2:3-benzo-1,1-dimethyl-1-silacyclo-hex-2-ene has been reported. This compound was prepared by the simultaneous addition of 3-(o-bromophenyl)-propyl bromide and dichlorodimethylsilane to excess magnesium in tetra-hydrofuran. The six-membered ring organosilicon compound was readily brominated by N-bromosuccinimide to give the 4-derivative. Attempts were then made to synthesize the 4-cyano and the 4-carboxylate derivatives from this bromination product. Experimental data are also given for an attempted preparation of 2:3-benzo-4-(2-dimethylaminoethoxy)-1,1-dimethyl-1-silacyclohex-2-ene. === Pharmaceutical Sciences, Faculty of === Graduate
author Lo, Daniel Ching-Shun
author_facet Lo, Daniel Ching-Shun
author_sort Lo, Daniel Ching-Shun
title Synthesis of 2:3-benzo-1, 1-dimethyl-1-silacyclohex-2-ene and derivatives
title_short Synthesis of 2:3-benzo-1, 1-dimethyl-1-silacyclohex-2-ene and derivatives
title_full Synthesis of 2:3-benzo-1, 1-dimethyl-1-silacyclohex-2-ene and derivatives
title_fullStr Synthesis of 2:3-benzo-1, 1-dimethyl-1-silacyclohex-2-ene and derivatives
title_full_unstemmed Synthesis of 2:3-benzo-1, 1-dimethyl-1-silacyclohex-2-ene and derivatives
title_sort synthesis of 2:3-benzo-1, 1-dimethyl-1-silacyclohex-2-ene and derivatives
publisher University of British Columbia
publishDate 2011
url http://hdl.handle.net/2429/36704
work_keys_str_mv AT lodanielchingshun synthesisof23benzo11dimethyl1silacyclohex2eneandderivatives
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