Tyrosyl-DNA phosphodiesterase 1 (Tdp1) : from spinocerebellar ataxia to roles in mitochondrial DNA repair and cancer therapy
Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a 3’-DNA phosphodiesterase that resolves a variety of physiological and drug-induced 3’DNA-blocking lesions. This activity makes Tdp1 an important component of the base-excision repair pathway. While the biochemical activity of Tdp1 has been extensively s...
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| Language: | English |
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University of British Columbia
2017
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| Online Access: | http://hdl.handle.net/2429/61100 |