Probing protein small ligand binding dynamics by hydrogen/deuterium exchange and electrospray ionization mass spectrometry
Cellular Retinoic acid binding protein I (CRABP I), a member of intracellular lipid binding proteins (iLBPs), binds physiologically to a mostly hydrophobic ligand, all-trans Retinoic Acid (RA). The binding site is inside an internal cavity, inaccessible in a static apo-protein conformation. Binding...
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| Language: | ENG |
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ScholarWorks@UMass Amherst
2005
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| Online Access: | https://scholarworks.umass.edu/dissertations/AAI3163719 |