To identify novel oncogenes for the design of novel tools for diagnosis and treatment of cancer

• Main Author: Mandiramoorthy, Selva Kumar
• Format: Others
• Language: English
• Published: Högskolan i Skövde, Institutionen för biovetenskap 2018
• Subjects: Biological Sciences; Biologiska vetenskaper
• Online Access: http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-16544

Cancer is a disease caused by an uncontrolled cell growth that destroys the healthy tissue of the body. It is one of the deadliest diseases in the world that alters many cellular mechanisms and features. In this report, a list of 22 upregulated oncogenes is studied to identify the novel oncogene. The need to determine the novel oncogene is to develop the anti-cancer agent. To determine the novel oncogene, gene enrichment analysis (GEA) was performed. It is a method to identify classes of genes that are over-represented in the large set of genes to determine the phenotypes of the organisms. DAVID and PANTHER are the methods used to carry on this study as it has Gene Ontology (GO) embedded in it. The GEA uses fishers exact test to determine the enriched gene by the standard p-value of 0.05. To further study the oncogene Network Enrichment Analysis was performed with EVINET. We found that microtubule was significantly enriched in NEA. The genes significantly enriched for GO microtubule were studied. The significantly enriched microtubule in NEA might then be used as a target for anti-cancer agent and used to develop the drug in the future.