Identification of a Genetic Network in the Budding Yeast Cell Cycle

• Main Author: Fransson, Martin
• Format: Others
• Language: English
• Published: Linköpings universitet, Institutionen för systemteknik 2004
• Subjects: Reglerteknik; Genetic network; Budding yeast cell; Auto regression; State-space model; Automatic control
• Online Access: http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-2389

By using AR/ARX-models on data generated by a nonlinear differential equation system representing a model for the cell-cycle control system in budding yeast, the interactions among proteins and thereby also to some extent the genes, are sought. A method consisting of graphical analysis of differences between estimates from two local linear models seems to make it possible to separate a set of linear equations from the nonlinear system. By comparing the properties of the estimations in the linear equations a set of approximate equations corresponding well to the real ones are found. A NARX model is tested on the same system to see whether it is possible to find the dependencies in one of the nonlinear differential equations. This approach did, for the choice of model, not work.