Microtubule associated proteins 1B and 1S : interactions with NR1 and NR3A
In previous studies the carboxyl-terminus of microtubule-associated protein 1S was shown to interact with the N-methyl-D-aspartate receptor subunit NR3A (Eriksson et. al.)1. In this study, interactions between three truncations of the microtubule-associated proteins 1B and one truncation of the m...
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Mälardalens högskola, Akademin för hållbar samhälls- och teknikutveckling
2008
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ndltd-UPSALLA1-oai-DiVA.org-mdh-11962013-01-08T13:17:24ZMicrotubule associated proteins 1B and 1S : interactions with NR1 and NR3AengBjörklund, StefanMälardalens högskola, Akademin för hållbar samhälls- och teknikutveckling2008NR1NR3ANMDAMicrotubule associated proteinsMAP1SMAP1BBioengineeringBioteknik In previous studies the carboxyl-terminus of microtubule-associated protein 1S was shown to interact with the N-methyl-D-aspartate receptor subunit NR3A (Eriksson et. al.)1. In this study, interactions between three truncations of the microtubule-associated proteins 1B and one truncation of the microtubule-associated protein 1S carboxyl-terminus and the N-methyl-D-aspartate receptor subunits NR1 and NR3A were examined. The study showed that an interaction occurred between amino acids 2167 to 2365 of the microtubule-associated protein 1B and NR3A. That region of microtubule associated protein 1B corresponds to a microtubule-binding region in the light chain. It has been shown in earlier studies (Reviewed in Halpain S. et a12, Riederer, BM. et.al3.) that the light chain is a active part of the protein that have been post translational cleaved. The MAP 1 proteins are present in all tissue but has higher concentrations in the Post Synaptic Density of neurons in the central nervous system. The N-methyl-D-aspartate receptors are present in glial cells and in the dendritic shafts of the central nervous system neurons (Eriksson et. al.)1 . The diseases were these proteins may play a part is mainly memory destructive diseases such as Alzheimers disease and in muscular dystrophy, but these assumptions are still being speculated. Student thesisinfo:eu-repo/semantics/masterThesistexthttp://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-1197application/pdfinfo:eu-repo/semantics/openAccess |
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NR1 NR3A NMDA Microtubule associated proteins MAP1S MAP1B Bioengineering Bioteknik |
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NR1 NR3A NMDA Microtubule associated proteins MAP1S MAP1B Bioengineering Bioteknik Björklund, Stefan Microtubule associated proteins 1B and 1S : interactions with NR1 and NR3A |
description |
In previous studies the carboxyl-terminus of microtubule-associated protein 1S was shown to interact with the N-methyl-D-aspartate receptor subunit NR3A (Eriksson et. al.)1. In this study, interactions between three truncations of the microtubule-associated proteins 1B and one truncation of the microtubule-associated protein 1S carboxyl-terminus and the N-methyl-D-aspartate receptor subunits NR1 and NR3A were examined. The study showed that an interaction occurred between amino acids 2167 to 2365 of the microtubule-associated protein 1B and NR3A. That region of microtubule associated protein 1B corresponds to a microtubule-binding region in the light chain. It has been shown in earlier studies (Reviewed in Halpain S. et a12, Riederer, BM. et.al3.) that the light chain is a active part of the protein that have been post translational cleaved. The MAP 1 proteins are present in all tissue but has higher concentrations in the Post Synaptic Density of neurons in the central nervous system. The N-methyl-D-aspartate receptors are present in glial cells and in the dendritic shafts of the central nervous system neurons (Eriksson et. al.)1 . The diseases were these proteins may play a part is mainly memory destructive diseases such as Alzheimers disease and in muscular dystrophy, but these assumptions are still being speculated. |
author |
Björklund, Stefan |
author_facet |
Björklund, Stefan |
author_sort |
Björklund, Stefan |
title |
Microtubule associated proteins 1B and 1S : interactions with NR1 and NR3A |
title_short |
Microtubule associated proteins 1B and 1S : interactions with NR1 and NR3A |
title_full |
Microtubule associated proteins 1B and 1S : interactions with NR1 and NR3A |
title_fullStr |
Microtubule associated proteins 1B and 1S : interactions with NR1 and NR3A |
title_full_unstemmed |
Microtubule associated proteins 1B and 1S : interactions with NR1 and NR3A |
title_sort |
microtubule associated proteins 1b and 1s : interactions with nr1 and nr3a |
publisher |
Mälardalens högskola, Akademin för hållbar samhälls- och teknikutveckling |
publishDate |
2008 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-1197 |
work_keys_str_mv |
AT bjorklundstefan microtubuleassociatedproteins1band1sinteractionswithnr1andnr3a |
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1716515262951325696 |